- Molecular NameIsocarboxazid
- SynonymIsocarbonazid; Isocarbossazide [Dcit]; Isocarboxazida [INN-Spanish]; Isocarboxazide; Isocarboxazide [INN-French]; Isocarboxazidum [INN-Latin]; Isocarboxyzid
- Weight231.255
- Drugbank_IDDB01247
- ACS_NO59-63-2
- Show 2D model
- LogP (experiment)1.49
- LogP (predicted, AB/LogP v2.0)1.36
- pka10.4
- LogD (pH=7, predicted)1.36
- Solubility (experiment)0.802 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.27
- LogSw (predicted, AB/LogsW2.0)1.59
- Sw (mg/ml) (predicted, ACD/Labs)1.25
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds4
- TPSA67.16
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class used as an antidepressant and anxiolytic.[
- Absorption_valueN/A
- Absorption (description)Rapidly absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMetabolised by oxidation to benzoic acid followed by glycine conjugation to form hippuric acid; an active metabolite, benzhydrazine, has been detected in animal studies but its formation in man has not been confirmed.
- Half life36 h
- ExcretionAbout 60% of a dose is excreted in the urine in 24 h and about 70% in 8 days; 90% of the excreted material is hippuric acid and about 2% is unchanged drug.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityToxic reactions from overdosage may occur in a matter of hours despite the long delay in onset of a therapeutic response. A fatality has been reported 24 h after ingestion of 400 mg.
- LD50 (rat)N/A
- LD50 (mouse)LD50=138 (intraperitoneal)