• Molecular NameGuanabenz
  • SynonymNA
  • Weight231.086
  • Drugbank_IDDB00629
  • ACS_NO5051-62-7
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)2.45
  • pkaN/A
  • LogD (pH=7, predicted)1.87
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.67
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.1
  • No.of HBond Donors4
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds2
  • TPSA76.76
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn alpha agonist of the alpha-2 type that is used as an antihypertensive drug. It is used to treat high blood pressure (hypertension).
  • Absorption_value78.0
  • Absorption (description)N/A
  • Caco_2-4.5
  • BioavailabilityN/A
  • Protein binding90.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmRapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite.
  • Half life6 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityExcessive contraction of the pupils, irritabilitylow blood pressure, sleepiness, slow heartbeat, sluggishness
  • LD50 (rat)N/A
  • LD50 (mouse)N/A