• Molecular NameNaproxen
  • SynonymNA
  • Weight230.263
  • Drugbank_IDDB00788
  • ACS_NO22204-53-1
  • Show 3D model
  • LogP (experiment)3.18
  • LogP (predicted, AB/LogP v2.0)3.26
  • pka4.15
  • LogD (pH=7, predicted)0.63
  • Solubility (experiment)0.0159 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-1.19
  • LogSw (predicted, AB/LogsW2.0)0.09
  • Sw (mg/ml) (predicted, ACD/Labs)0.12
  • No.of HBond Donors1
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds3
  • TPSA46.53
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA non-steroidal anti-inflammatory drug (NSAID) commonly used for the reduction of mild to moderate pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and the treatment of primary dysmenorrhea.
  • Absorption_value100.0
  • Absorption (description)N/A
  • Caco_2-4.83
  • Bioavailability86.0
  • Protein binding99.7
  • Volume of distribution (VD)0.16 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolically cleared by CYP2C9 (polymorphic) and CYP1A2.
  • Half life14 h
  • ExcretionRenal
  • Urinary Excretion5~6
  • Clerance0.13 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)LD50=248 mg/kg
  • LD50 (mouse)LD50=360 mg/kg