- Molecular NameClonidine
- SynonymChlornidinum; Clonidin; Clonidine HCl; Clonidinhydrochlorid; Clonidinum [INN-Latin]; ST 155BS
- Weight230.098
- Drugbank_IDDB00575
- ACS_NO4205-90-7
- Show 2D model
- LogP (experiment)2.278
- LogP (predicted, AB/LogP v2.0)1.95
- pka8.05
- LogD (pH=7, predicted)1.0
- Solubility (experiment)Soluble
- LogS (predicted, ACD/Labs)(ph=7)-1.74
- LogSw (predicted, AB/LogsW2.0)0.17
- Sw (mg/ml) (predicted, ACD/Labs)0.41
- No.of HBond Donors2
- No.of HBond Acceptors3
- No.of Rotatable Bonds1
- TPSA36.42
- StatusFDA approved
- Administrationoral, transdermal
- PharmacologyA medication used to treat several medical conditions. It is a direct-acting α2 adrenergic agonist.
- Absorption_value95.0
- Absorption (description)Well absorbed after oral administration; peak plasma concentrations reached within 3 to 5 h.
- Caco_2N/A
- Bioavailability95.0
- Protein binding30.0
- Volume of distribution (VD)2.1 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic to inactive metabolites
- Half life12 h
- ExcretionAbout 40 to 60% of a single dose is excreted in the urine as unchanged drug in 24 h, and about 20% of a dose is eliminated in the faeces in 4 days, probably via enterohepatic circulation. Several inactive metabolites have been detected in urine in small quantities.
- Urinary Excretion62
- Clerance3.1 ml/min/kg
- ToxicitySerious toxic effects have been reported after ingestion of doses of 0.4 to 4 mg by children and 4 to 11 mg by adults. However, recovery is usually rapid.
- LD50 (rat)LD50=150 mg/kg
- LD50 (mouse)LD50=130 (ubcutaneous); LD50=325 (intragastric)