• Molecular NameAmiloride
  • SynonymAmilorida [INN-Spanish]; Amiloride HCL; Amiloride hydrochloride; Amiloride hydrochloride hydrate; Amiloridum [INN-Latin]; AMR; Amyloride
  • Weight229.631
  • Drugbank_IDDB00594
  • ACS_NO2609-46-3
  • Show 2D model
  • LogP (experiment)0.1
  • LogP (predicted, AB/LogP v2.0)-1.04
  • pka8.7
  • LogD (pH=7, predicted)-1.25
  • Solubility (experiment)Slightly soluble
  • LogS (predicted, ACD/Labs)(ph=7)-4.77
  • LogSw (predicted, AB/LogsW2.0)1.32
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors8
  • No.of HBond Acceptors8
  • No.of Rotatable Bonds2
  • TPSA159.29
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA potassium-sparing diuretic, first approved for use in 1967 (then known as MK 870), used in the management of hypertension and congestive heart failure.
  • Absorption_value50.0
  • Absorption (description)Incompletely absorbed after oral administration
  • Caco_2N/A
  • Bioavailability50.0
  • Protein binding40.0
  • Volume of distribution (VD)5 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmIt does not appear to be metabolised.
  • Half life6~9 h
  • ExcretionAbout 50% of an oral dose is excreted unchanged in the urine and 40% is eliminated in the faeces in 72 h.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A