• Molecular NameNabumetone
  • SynonymNabumetona; Nabumetonum [INN-Latin]
  • Weight228.291
  • Drugbank_IDDB00461
  • ACS_NO42924-53-8
  • Show 3D model
  • LogP (experiment)3.08
  • LogP (predicted, AB/LogP v2.0)3.44
  • pkaN/A
  • LogD (pH=7, predicted)3.44
  • Solubility (experiment)0.0587 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.42
  • LogSw (predicted, AB/LogsW2.0)0.03
  • Sw (mg/ml) (predicted, ACD/Labs)0.09
  • No.of HBond Donors0
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds4
  • TPSA26.3
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA non-steroidal anti-inflammatory drug
  • Absorption_value80.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability35.0
  • Protein bindingN/A
  • Volume of distribution (VD)7.5 L (steady state); ranges between 5 and 10 L (0.1 to 0.2 L/kg).
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic, to active metabolite 6-methoxy-2-naphthylacetic acid; 6-MNA
  • Half life6-MNA, 22 to 27 h (young healthy subjects), 25 to 34 h (elderly).
  • ExcretionRenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A