- Molecular NameNitroglycerin
- SynonymGlyceryl trinitrate; NG; nitroglycerin ointment; Nitroglycerine; NTG; TNG; Trinitroglycerin
- Weight227.085
- Drugbank_IDDB00727
- ACS_NO55-63-0
- Show 2D model
- LogP (experiment)2.2
- LogP (predicted, AB/LogP v2.0)2.0
- pkaN/A
- LogD (pH=7, predicted)2.0
- Solubility (experiment)1.37 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.31
- LogSw (predicted, AB/LogsW2.0)1.23
- Sw (mg/ml) (predicted, ACD/Labs)1.1
- No.of HBond Donors0
- No.of HBond Acceptors12
- No.of Rotatable Bonds8
- TPSA174.18
- StatusFDA approved
- AdministrationN/A
- PharmacologyUsed as a heart medication (under the trade names Nitrospan, Nitrostat, and Tridil, amongst others). It is used as a medicine for angina pectoris (ischaemic heart disease) in tablets, ointment, solution for intravenous use, transdermal patches (Trinipatch, Transderm Nitro, Nitro-Dur), or sprays administered sublingually (Nitrolingual Pump Spray, Natispray). Patients who experience angina when doing certain physical activities, can often prevent symptoms by taking nitroglycerin 5 to 10 minutes before the activity also allowing more freedom to enjoy.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability1.0
- Protein bindingN/A
- Volume of distribution (VD)3.3 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic, cytochrome P450 (P450) is a key enzyme of organic nitrate biotransformation
- Half life2.3 h
- ExcretionN/A
- Urinary Excretion<1
- Clerance195 ml/min/kg
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A