- Molecular NameAlclofenac
- SynonymNA
- Weight226.659
- Drugbank_IDN/A
- ACS_NO22131-79-9
- Show 2D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)2.54
- pka4.6
- LogD (pH=7, predicted)-0.2
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-0.02
- LogSw (predicted, AB/LogsW2.0)0.46
- Sw (mg/ml) (predicted, ACD/Labs)0.5
- No.of HBond Donors1
- No.of HBond Acceptors3
- No.of Rotatable Bonds5
- TPSA46.53
- StatusEU withdrawn
- AdministrationN/A
- PharmacologyA non-steroidal anti-inflammatory drug.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability66.0
- Protein binding99.0
- Volume of distribution (VD)0.1 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is metabolised by glucuronic acid conjugation; there is some conjugation with glycine, deallylation to form 3-chloro-4-hydroxyphenylacetic acid, and hydroxylation to form 3-chloro-4-(2,3-dihydroxypropyloxy)phenylacetic acid which may be methylated; an epoxide metabolite has also been identified.
- Half life1.5~5.5 h
- ExcretionUp to about 90% of an oral dose is excreted in the urine in 24 h, mostly as unchanged drug and the glucuronide conjugate.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityThe following adverse effects were reported in a clinical trial study: gastrointestinal disturbance, skin rush, generalized pruritus
- LD50 (rat)N/A
- LD50 (mouse)N/A