- Molecular NameAmobarbital
- SynonymNA
- Weight226.276
- Drugbank_IDDB01351
- ACS_NO57-43-2
- Show 3D model
- LogP (experiment)2.07
- LogP (predicted, AB/LogP v2.0)0.58
- pka7.78
- LogD (pH=7, predicted)0.58
- Solubility (experiment)0.77 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)0.65
- LogSw (predicted, AB/LogsW2.0)1.51
- Sw (mg/ml) (predicted, ACD/Labs)1.28
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds4
- TPSA82.25
- StatusFDA approved
- AdministrationOral, IM, IV, Rectal
- PharmacologyA drug that is a barbiturate derivative. It has sedative-hypnotic and analgesic properties.
- Absorption_value95.0
- Absorption (description)Readily and almost completely absorbed after oral administration.
- Caco_2N/A
- Bioavailability95.0
- Protein binding50.0
- Volume of distribution (VD)1 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is metabolised by hydroxylation to give the major metabolite 3′-hydroxyamobarbital, which has about one-third of the activity of the parent substance.
- Half life24 h
- ExcretionAbout 80 to 90% of a dose is excreted in the urine in 6 days, of which 30 to 50% is 3′-hydroxyamobarbital, up to 30% is N-β-d-glucopyranosylamobarbital, and about 1% is unchanged drug. The metabolite pattern appears to be genetically determined. 5-(3′-Carboxybutyl)-5-ethylbarbituric acid has also been identified as a metabolite in urine. About 5% of a dose is eliminated in the faeces in 6 days.
- Urinary ExcretionN/A
- ClerancePlasma clearance, about 0.5 mL/min/kg.
- ToxicityThe estimated minimum lethal dose is 1.5 g. Toxic effects are associated with plasma concentrations greater than 9 mg/L and fatalities with postmortem blood concentrations of 9 to 26 to 72 mg/L. In a review of 55 cases of fatal overdosage, postmortem blood concentrations were in the range 13 to 96 mg/L. [R. C. Gupta and J. Kofed,Can. Med. Assoc. J.,1966, 94, 863–865.]
- LD50 (rat)N/A
- LD50 (mouse)N/A