- Molecular NameTerbutaline
- SynonymTerbutalin; Terbutalina [Dcit]; Terbutaline Sulfate; Terbutalino [INN-Spanish]; Terbutalinum [INN-Latin]
- Weight225.288
- Drugbank_IDDB00871
- ACS_NO23031-25-6
- Show 3D model
- LogP (experiment)0.08
- LogP (predicted, AB/LogP v2.0)0.23
- pka8.7, 10.0, 11.0
- LogD (pH=7, predicted)-2.51
- Solubility (experiment)213 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)0.43
- LogSw (predicted, AB/LogsW2.0)56.13
- Sw (mg/ml) (predicted, ACD/Labs)10.87
- No.of HBond Donors4
- No.of HBond Acceptors4
- No.of Rotatable Bonds4
- TPSA72.72
- StatusFDA approved
- AdministrationSQ, Oral, Inhaled
- PharmacologyA β2-adrenergic receptor agonist, used as a fast-acting bronchodilator (often used as a short-term asthma treatment) and as a tocolytic to delay premature labour.
- Absorption_value63.0
- Absorption (description)N/A
- Caco_2-6.38
- Bioavailability14.0
- Protein binding205.0
- Volume of distribution (VD)1.8 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmGI tract (oral), liver; CYP450: unknown
- Half life5.5~5.9 h
- Excretionurine 90% (60% unchanged), bile/faeces
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityTerbutaline Sulfate: Oral LD50(rat) = 8.7 g/kg; Oral LD50(mouse) = 205 mg/kg; Oral LD50(dog) = 1.5 g/kg; IP LD50(rat)= 220 mg/kg ; IP LD50(mouse) = 130 mg/kg; Oral LD50(rabbit) = >8 g/kg; IV LD50(mouse) = 36 mg/kg; IV LD50(dog) = 116 mg/kg; IV LD50(rabbit) = 110 mg/kg
- LD50 (rat)N/A
- LD50 (mouse)N/A