- Molecular NameProcarbazine
- SynonymIbenzmethyzin; Ibenzmethyzine; Ibenzmethyzine hydrochloride; IBZ; MBH; MIH; MIH Hydrochloride; PCB; PCB hydrochloride; PCX; Procarbazin; Procarbazin [German]; Procarbazina [INN-Spanish]; Procarbazine hydrochloride; Procarbazinum [INN-Latin]
- Weight221.304
- Drugbank_IDDB01168
- ACS_NO671-16-9
- Show 3D model
- LogP (experiment)0.06
- LogP (predicted, AB/LogP v2.0)0.9
- pka6.8
- LogD (pH=7, predicted)0.76
- Solubility (experiment)1.42 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-0.8
- LogSw (predicted, AB/LogsW2.0)1.41
- Sw (mg/ml) (predicted, ACD/Labs)3.24
- No.of HBond Donors3
- No.of HBond Acceptors4
- No.of Rotatable Bonds5
- TPSA53.16
- StatusFDA approved
- AdministrationOral (Gel Capsule), intravenous
- PharmacologyAn antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers (such as Glioblastoma multiforme).
- Absorption_value100.0
- Absorption (description)Procarbazine is rapidly and completely absorbed.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmProcarbazine is metabolized primarily in the liver and kidneys. The drug appears to be auto-oxidized to the azo derivative with the release of hydrogen peroxide. The azo derivative isomerizes to the hydrazone, and following hydrolysis splits into a benzylaldehyde derivative and methylhydrazine. The methylhydrazine is further degraded to CO2 and CH4 and possibly hydrazine, whereas the aldehyde is oxidized to N-isopropylterephthalamic acid, which is excreted in the urine.
- Half life10 min
- ExcretionRenal
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)LD50=785 mg/kg
- LD50 (mouse)N/A