• Molecular NamePrilocaine
  • SynonymNA
  • Weight220.316
  • Drugbank_IDDB00750
  • ACS_NO721-50-6
  • Show 3D model
  • LogP (experiment)2.1
  • LogP (predicted, AB/LogP v2.0)1.78
  • pka7.9
  • LogD (pH=7, predicted)0.37
  • Solubility (experiment)0.541 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-1.16
  • LogSw (predicted, AB/LogsW2.0)5.13
  • Sw (mg/ml) (predicted, ACD/Labs)3.01
  • No.of HBond Donors2
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds5
  • TPSA41.13
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyIn its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commoly used for intravenous regional anaesthesia (IVRA).
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding50.0
  • Volume of distribution (VD)2.5~4.9 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic and renal
  • Half life1~2 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A