- Molecular NameMeprobamate
- SynonymDEA No; 2820; Meprobamat [German]; Meprobamato [INN-Spanish]; Meprobamato [Italian]; Meprobamatum [INN-Latin]; Meprobamic acid; Procarbamide
- Weight218.253
- Drugbank_IDDB00371
- ACS_NO57-53-4
- Show 3D model
- LogP (experiment)0.7
- LogP (predicted, AB/LogP v2.0)1.02
- pkaN/A
- LogD (pH=7, predicted)1.02
- Solubility (experiment)4700 mg/L
- LogS (predicted, ACD/Labs)(ph=7)-1.4
- LogSw (predicted, AB/LogsW2.0)2.8
- Sw (mg/ml) (predicted, ACD/Labs)8.72
- No.of HBond Donors4
- No.of HBond Acceptors6
- No.of Rotatable Bonds8
- TPSA104.64
- StatusFDA approved
- AdministrationN/A
- PharmacologyA carbamate derivative which is used as an anxiolytic drug.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding20.0
- Volume of distribution (VD)0.7 L/kg
- Blood/Plasma Partitioning ratio (D_blood)Plasma : whole blood ratio, about 0.2 to 0.3.
- MetabollsmIt is widely distributed and mainly metabolised in the liver.
- Half life11 h
- ExcretionAbout 90% of a dose is excreted in the urine in 24 h, with about 10 to 20% of the dose as unchanged drug and the remainder as metabolites, mainly 2-hydroxypropylmeprobamate and meprobamate N-glucuronide. About 10% of the dose is eliminated in the faeces. Meprobamate crosses the placenta. Levels in breast milk may be up to 4 times higher than those found in plasma.Meprobamate is a minor metabolite of tybamate and is a metabolite of carisoprodol.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityThe estimated minimum lethal dose is 12 g, although recovery has occurred after much larger doses. Blood concentrations greater than about 50 mg/L may cause coma and fatalities have usually been associated with blood concentrations greater than about 70 mg/L.
- LD50 (rat)LD50=1600
- LD50 (mouse)LD50=600