• Molecular NameMethoxsalen
  • SynonymNA
  • Weight216.192
  • Drugbank_IDDB00553
  • ACS_NO298-81-7
  • Show 3D model
  • LogP (experiment)1.78
  • LogP (predicted, AB/LogP v2.0)2.08
  • pkaN/A
  • LogD (pH=7, predicted)2.08
  • Solubility (experiment)0.0473 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.81
  • LogSw (predicted, AB/LogsW2.0)0.15
  • Sw (mg/ml) (predicted, ACD/Labs)0.34
  • No.of HBond Donors0
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds1
  • TPSA48.67
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA drug used to treat psoriasis, eczema, vitiligo, and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMethoxsalen is rapidly metabolized. Approximately 95% of the drug is excreted as a series of metabolites in the urine within 24 hours. The exact mechanism of action of methoxsalen with the epidermal melanocytes and keratinocytes is not known. The best known biochemical reaction of methoxsalen is with DNA. Methoxsalen, upon photoactivation, conjugates and forms covalent bonds with DNA which leads to the formation of both monofunctional (addition to a single strand of DNA) and bifunctional (crosslinking of psoralen to both strands of DNA) adducts. Reactions with proteins have also been described.
  • Half life2 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityThe most commonly reported side effect of methoxsalen alone is nausea, which occurs with approximately 10% of all patients. This effect may be minimized or avoided by instructing the patient to take methoxsalen in milk or food, or to divide the dose into two portions, taken approximately one-half hour apart. Other effects include nervousness, insomnia, and depression. Main side effects of combined methoxsalen/uva therapy include pruritis, and mild, transient erythema. Other adverse reactions include include edema, dizziness, headache, malaise, depression, hypopigmentation, vesiculation and bullae formation, non-specific rash, herpes simplex, miliaria, urticaria, folliculitis, gastrointestinal disturbances, cutaneous tenderness, leg cramps, hypotension, and extension of psoriasis.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A