- Molecular NameGuanadrel
- SynonymGuanadrelum [INN-Latin], Guanadrel Sulfate
- Weight213.281
- Drugbank_IDDB00226
- ACS_NO40580-59-4
- Show 3D model
- LogP (experiment)0.781
- LogP (predicted, AB/LogP v2.0)0.69
- pkaN/A
- LogD (pH=7, predicted)-2.41
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.51
- LogSw (predicted, AB/LogsW2.0)3.4
- Sw (mg/ml) (predicted, ACD/Labs)12.28
- No.of HBond Donors4
- No.of HBond Acceptors5
- No.of Rotatable Bonds3
- TPSA80.36
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn antihypertensive agent. A postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump; guanadrel slowly displaces norepinephrine from its storage in nerve endings and thereby blocks the release of norepinephrine normally produced by nerve stimulation.
- Absorption_value80.0
- Absorption (description)Rapidly and readily absorbed from the gastrointestinal tract.
- Caco_2N/A
- Bioavailability85.0
- Protein binding20.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic
- Half life10 h
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySide effects include dizziness, drowsiness, headache, constipation, diarrhea, gas pains, loss of appetite, fatigue, and nasal congestion.
- LD50 (rat)N/A
- LD50 (mouse)N/A