- Molecular NameButabarbital
- SynonymButabarbital Sodium; Butabarbitone; Butrate; Secbubarbital; Secbutabarbital; Secbutobarbital; Secbutobarbitone; Sodium Butabarbital
- Weight212.249
- Drugbank_IDDB00237
- ACS_NO143-81-7
- Show 2D model
- LogP (experiment)1.631
- LogP (predicted, AB/LogP v2.0)1.41
- pka7.89
- LogD (pH=7, predicted)1.36
- Solubility (experiment)1.36 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.22
- LogSw (predicted, AB/LogsW2.0)0.94
- Sw (mg/ml) (predicted, ACD/Labs)1.16
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds3
- TPSA75.27
- StatusFDA approved
- AdministrationN/A
- PharmacologyA prescription barbiturate sleep aid. Butabarbital has a particularly fast onset of effects and short duration of action compared to other barbiturates, which makes it useful for certain applications such as treating severe insomnia and relieving anxiety before surgical procedures; however it is also relatively dangerous particularly when combined with alcohol, and so is now rarely used,
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)0.8
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half lifeN/A
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySigns of overdose include confusion (severe), decrease in or loss of reflexes, drowsiness (severe), fever, irritability (continuing), low body temperature, poor judgment, shortness of breath or slow or troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness (severe).
- LD50 (rat)N/A
- LD50 (mouse)N/A