- Molecular NameZonisamide
- SynonymZonisamida [Spanish]; zonisamide; Zonisamidum [Latin]
- Weight212.229
- Drugbank_IDDB00909
- ACS_NO68291-97-4
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)0.55
- pka10.2
- LogD (pH=7, predicted)0.55
- Solubility (experiment)Slightly soluble
- LogS (predicted, ACD/Labs)(ph=7)-1.97
- LogSw (predicted, AB/LogsW2.0)0.87
- Sw (mg/ml) (predicted, ACD/Labs)2.29
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds2
- TPSA94.57
- StatusFDA approved
- AdministrationN/A
- PharmacologyA sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures for adults; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure.
- Absorption_value100.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability100.0
- Protein binding39.0
- Volume of distribution (VD)1.2~1.8 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmPrimary routes of metabolism involve reductive cleavage of the isoxazole ring (CYP3A4) and N-acetylation.
- Half life63 h
- ExcretionRenal
- Urinary Excretion29~48
- Clerance0.13 ml/min/kg
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A