• Molecular NameZonisamide
  • SynonymZonisamida [Spanish]; zonisamide; Zonisamidum [Latin]
  • Weight212.229
  • Drugbank_IDDB00909
  • ACS_NO68291-97-4
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)0.55
  • pka10.2
  • LogD (pH=7, predicted)0.55
  • Solubility (experiment)Slightly soluble
  • LogS (predicted, ACD/Labs)(ph=7)-1.97
  • LogSw (predicted, AB/LogsW2.0)0.87
  • Sw (mg/ml) (predicted, ACD/Labs)2.29
  • No.of HBond Donors2
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds2
  • TPSA94.57
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures for adults; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure.
  • Absorption_value100.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability100.0
  • Protein binding39.0
  • Volume of distribution (VD)1.2~1.8 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmPrimary routes of metabolism involve reductive cleavage of the isoxazole ring (CYP3A4) and N-acetylation.
  • Half life63 h
  • ExcretionRenal
  • Urinary Excretion29~48
  • Clerance0.13 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A