• Molecular NameVarenicline
  • SynonymCP-526,555; varenicline; Varenicline tartrate
  • Weight211.268
  • Drugbank_IDDB01273
  • ACS_NO249296-44-4
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)1.4
  • pkaN/A
  • LogD (pH=7, predicted)-1.23
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)0.48
  • LogSw (predicted, AB/LogsW2.0)1.56
  • Sw (mg/ml) (predicted, ACD/Labs)2.61
  • No.of HBond Donors1
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds0
  • TPSA37.81
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA prescription medication used to treat smoking addiction.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding20.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolism is limited (<10%). Most of the active compound is excreted renally (81%). A small proportion is glucuronidated, oxidated, N-formylated or conjugated to a hexose.
  • Half life24 h
  • ExcretionMost of the active compound is excreted renally (92–93%). A small proportion is glucuronidated, oxidated, N-formylated or conjugated to a hexose.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A