- Molecular NameVarenicline
- SynonymCP-526,555; varenicline; Varenicline tartrate
- Weight211.268
- Drugbank_IDDB01273
- ACS_NO249296-44-4
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)1.4
- pkaN/A
- LogD (pH=7, predicted)-1.23
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.48
- LogSw (predicted, AB/LogsW2.0)1.56
- Sw (mg/ml) (predicted, ACD/Labs)2.61
- No.of HBond Donors1
- No.of HBond Acceptors3
- No.of Rotatable Bonds0
- TPSA37.81
- StatusFDA approved
- AdministrationN/A
- PharmacologyA prescription medication used to treat smoking addiction.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein binding20.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMetabolism is limited (<10%). Most of the active compound is excreted renally (81%). A small proportion is glucuronidated, oxidated, N-formylated or conjugated to a hexose.
- Half life24 h
- ExcretionMost of the active compound is excreted renally (92–93%). A small proportion is glucuronidated, oxidated, N-formylated or conjugated to a hexose.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A