- Molecular NameOrciprenaline
- SynonymMetaproterenol; Metaproterenol Sulfate; Orciprenalina [INN-Spanish]; Orciprenaline Sulfate; Orciprenalinum [INN-Latin]
- Weight211.261
- Drugbank_IDDB00816
- ACS_NO586-06-1
- Show 2D model
- LogP (experiment)0.2
- LogP (predicted, AB/LogP v2.0)-0.08
- pkapKa9.0 (—OH), 10.1 (—NH—), 11.4 (—OH), (25°)
- LogD (pH=7, predicted)-2.77
- Solubility (experiment)0.0097 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)0.1
- LogSw (predicted, AB/LogsW2.0)142.85
- Sw (mg/ml) (predicted, ACD/Labs)5.99
- No.of HBond Donors4
- No.of HBond Acceptors4
- No.of Rotatable Bonds4
- TPSA72.72
- StatusFDA approved
- AdministrationInhalation / tablets
- PharmacologyA bronchodilator used in the treatment of asthma.
- Absorption_value43.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability20.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmGastrointestinal and hepatic. The major metabolite, metaproterenol-3-0-sulfate, is produced in the gastrointestinal tract. Alupent is not metabolized by catechol-0-methyltransferase nor have glucuronide conjugates been isolated to date.
- Half life6 h
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose include angina, hypertension or hypotension, arrhythmias, nervousness, headache, tremor, dry mouth, palpitation, nausea, dizziness, fatigue, malaise and insomnia.
- LD50 (rat)LD50=42 mg/kg
- LD50 (mouse)N/A