• Molecular NameMethoxamine
  • SynonymNA
  • Weight211.261
  • Drugbank_IDDB00723
  • ACS_NO390-28-3
  • Show 2D model
  • LogP (experiment)0.4
  • LogP (predicted, AB/LogP v2.0)0.39
  • pka9.2
  • LogD (pH=7, predicted)-1.53
  • Solubility (experiment)185 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)0.68
  • LogSw (predicted, AB/LogsW2.0)8.37
  • Sw (mg/ml) (predicted, ACD/Labs)27.86
  • No.of HBond Donors3
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds4
  • TPSA64.71
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn α1-adrenergic receptor agonist, similar in structure to phenylephrine and 2,5-DMA. It induces vasoconstriction of skin and splanchnic blood vessels, thereby increasing peripheral vascular resistance and raising mean arterial blood pressure. Because of its hypertensive effects, it may evoke a compensatory reflex bradycardia via the baroreceptors.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMethoxamine is demethylated in rats
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A