- Molecular NameAprobarbital
- SynonymNA
- Weight210.233
- Drugbank_IDDB01352
- ACS_NO77-02-1
- Show 2D model
- LogP (experiment)1.15
- LogP (predicted, AB/LogP v2.0)1.28
- pka8.0
- LogD (pH=7, predicted)1.23
- Solubility (experiment)4.08 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.95
- LogSw (predicted, AB/LogsW2.0)3.75
- Sw (mg/ml) (predicted, ACD/Labs)2.06
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds3
- TPSA75.27
- StatusFDA approved
- AdministrationN/A
- PharmacologyA barbiturate derivative invented in the 1920s by Ernst Preiswerk. It has sedative, hypnotic and anticonvulsant properties, and was used primarily for the treatment of insomnia.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein binding67.5
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half life0.5~1.5 days
- ExcretionSlowly excreted in the urine, mainly as metabolites, less than 3% of a dose being excreted as unchanged drug in 24 h. About 12% of a dose is excreted in the urine as the diol derivative and 4% as N-hydroxyaprobarbital in 3 days, together with 9% as unchanged drug.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityThe estimated minimum lethal dose is 2 g. Plasma concentrations greater than 40 mg/L are usually associated with toxic effects; concentrations greater than 50 mg/L may be fatal. In 4 cases of death attributed to overdoses ranging from 2.5 to 7.7 g, ante-mortem serum concentrations ranged from 120 to 150 mg/L. In 44 cases of overdose in which the patients subsequently recovered, the serum concentrations 24 h after ingestion were in the range 40 to 130 mg/L. [P. Lous,Acta Pharmacol.Toxicol.,1954, 10, 261–280.]
- LD50 (rat)N/A
- LD50 (mouse)N/A