• Molecular NamePilocarpine
  • SynonymAdsorbocarpine; Beta-pilocarpine hydrochloride; Pilocarpin; Pilocarpine chloride; Pilocarpine HCl; Pilocarpine hydrochloride; Pilocarpine monohydrochloride; Pilocarpine muriate; Pilokarpin; Pilokarpin monohydrochloride; Spersacarpine; Spersacarpine hydrochloride
  • Weight208.261
  • Drugbank_IDDB01085
  • ACS_NO92-13-7
  • Show 3D model
  • LogP (experiment)0.12
  • LogP (predicted, AB/LogP v2.0)0.69
  • pka1.6, 7.1
  • LogD (pH=7, predicted)0.38
  • Solubility (experiment)1000 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.62
  • LogSw (predicted, AB/LogsW2.0)2.94
  • Sw (mg/ml) (predicted, ACD/Labs)24.64
  • No.of HBond Donors0
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds3
  • TPSA44.12
  • StatusFDA approved
  • Administrationgtts, p.o.
  • PharmacologyA muscarinic alkaloid obtained from the leaves of tropical American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at the muscarinic acetylcholine receptor M3 due to its topical application, e.g., in glaucoma and xerostomia.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life0.76 h (5 mg), 1.35 h (10 mg)
  • Excretionurine
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityThe most frequent adverse experiences associated with Pilocarpine were a consequence of the expected pharmacologic effects and include sweating, nausea, rhinitis, diarrhea, chills, flushing, urinary frequency, dizziness, asthenia.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A