- Molecular NamePilocarpine
- SynonymAdsorbocarpine; Beta-pilocarpine hydrochloride; Pilocarpin; Pilocarpine chloride; Pilocarpine HCl; Pilocarpine hydrochloride; Pilocarpine monohydrochloride; Pilocarpine muriate; Pilokarpin; Pilokarpin monohydrochloride; Spersacarpine; Spersacarpine hydrochloride
- Weight208.261
- Drugbank_IDDB01085
- ACS_NO92-13-7
- Show 3D model
- LogP (experiment)0.12
- LogP (predicted, AB/LogP v2.0)0.69
- pka1.6, 7.1
- LogD (pH=7, predicted)0.38
- Solubility (experiment)1000 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-0.62
- LogSw (predicted, AB/LogsW2.0)2.94
- Sw (mg/ml) (predicted, ACD/Labs)24.64
- No.of HBond Donors0
- No.of HBond Acceptors4
- No.of Rotatable Bonds3
- TPSA44.12
- StatusFDA approved
- Administrationgtts, p.o.
- PharmacologyA muscarinic alkaloid obtained from the leaves of tropical American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at the muscarinic acetylcholine receptor M3 due to its topical application, e.g., in glaucoma and xerostomia.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half life0.76 h (5 mg), 1.35 h (10 mg)
- Excretionurine
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityThe most frequent adverse experiences associated with Pilocarpine were a consequence of the expected pharmacologic effects and include sweating, nausea, rhinitis, diarrhea, chills, flushing, urinary frequency, dizziness, asthenia.
- LD50 (rat)N/A
- LD50 (mouse)N/A