• Molecular NameToloxatone
  • SynonymNA
  • Weight207.229
  • Drugbank_IDN/A
  • ACS_NO29218-27-7
  • Show 2D model
  • LogP (experiment)1.88
  • LogP (predicted, AB/LogP v2.0)1.02
  • pkaN/A
  • LogD (pH=7, predicted)1.02
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.27
  • LogSw (predicted, AB/LogsW2.0)5.87
  • Sw (mg/ml) (predicted, ACD/Labs)1.12
  • No.of HBond Donors1
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds2
  • TPSA49.77
  • StatusN/A
  • AdministrationN/A
  • PharmacologyAn antidepressant and monoamine oxidase inhibitor (MAOI). It acts as a selective reversible inhibitor of MAO-A (RIMA).
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability56.0
  • Protein binding51.0
  • Volume of distribution (VD)1.09 to 1.64 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life0.88~2.46 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A