• Molecular NameAmfepramone, Diethylpropion
  • SynonymN/A
  • Weight205.301
  • Drugbank_IDDB00937
  • ACS_NO90-84-6
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)2.64
  • pkaN/A
  • LogD (pH=7, predicted)1.6
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.98
  • LogSw (predicted, AB/LogsW2.0)4.31
  • Sw (mg/ml) (predicted, ACD/Labs)0.72
  • No.of HBond Donors0
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds5
  • TPSA20.31
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA stimulant drug of the phenethylamine, amphetamine, and cathinone chemical classes that is used as an appetite suppressant.
  • Absorption_value95.0
  • Absorption (description)Diethylpropion is rapidly absorbed from the GI tract after oral administration.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolised by N-dealkylation, reduction, deamination, and N-hydroxylation primarily to active metabolites; keto reduction is stereoselective resulting in the formation of threo-hydroxylated metabolites; glucuronide formation also occurs along with the formation of hippuric and mandelic acids.
  • Half lifeDerived from urinary excretion data, 1.5~3 h in subjects whose urines are acidic.
  • ExcretionAbout 80 to 90% of a dose is excreted in the urine; the amount excreted in the urine is reduced when the urine is alkaline; of the urinary excreted material, N-ethylaminopropiophenone, norephedrine (phenylpropanolamine), and hippuric acid are the main metabolites together with small amounts of unchanged drug, aminopropiophenone, N-diethylnorephedrine, and N-ethylnorephedrine. Diethylpropion crosses the blood–brain barrier and the placenta. The drug and its metabolites are distributed into breast milk.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityManifestation of acute overdosage include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, and panic states. The estimated minimum lethal doses are 200 mg for a child and 2 g for an adult.
  • LD50 (rat)N/A
  • LD50 (mouse)600 mg/kg