- Molecular NameDactinomycin
- SynonymAD; Antibiotic From Streptomyces Parvullus; Dactinomicina [INN-Spanish]; Dactinomycine [INN-French]; Dactinomycinum [INN-Latin]
- Weight1255.44
- Drugbank_IDDB00970
- ACS_NO50-76-0
- Show 2D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)N/A
- pkaN/A
- LogD (pH=7, predicted)N/A
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)N/A
- LogSw (predicted, AB/LogsW2.0)N/A
- Sw (mg/ml) (predicted, ACD/Labs)N/A
- No.of HBond DonorsN/A
- No.of HBond AcceptorsN/A
- No.of Rotatable BondsN/A
- TPSAN/A
- StatusFDA approved
- AdministrationN/A
- PharmacologyA class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces, of which the most significant is actinomycin D.
- Absorption_valueN/A
- Absorption (description)Dactinomycin is rapidly distributed following intravenous administration and concentrates in bone marrow and nucleated cells.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmThe drug undergoes minimal metabolism
- Half life36 h
- ExcretionSlowly excreted in urine (about 10% as unchanged drug) and via bile in faeces (about 50% as the unchanged drug).
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A