• Molecular NameSevoflurane
  • SynonymSevofluran; Sevoflurano [INN-Spanish]; Sevofluranum [INN-Latin]
  • Weight200.053
  • Drugbank_IDDB01236
  • ACS_NO28523-86-6
  • Show 2D model
  • LogP (experiment)2.212
  • LogP (predicted, AB/LogP v2.0)2.23
  • pkaN/A
  • LogD (pH=7, predicted)2.23
  • Solubility (experiment)Slightly soluble
  • LogS (predicted, ACD/Labs)(ph=7)-1.75
  • LogSw (predicted, AB/LogsW2.0)0.79
  • Sw (mg/ml) (predicted, ACD/Labs)3.53
  • No.of HBond Donors0
  • No.of HBond Acceptors1
  • No.of Rotatable Bonds4
  • TPSA9.23
  • StatusFDA approved
  • Administrationinhaled
  • PharmacologyA sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia.
  • Absorption_valueN/A
  • Absorption (description)Rapidly absorbed into circulation via the lungs, however solubility in the blood is low.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmRelatively little biotransformation, only 5% is metabolized by cytochrome P450 CYP2E1 to hexafluoroisopropanol (HFIP) with release of inorganic fluoride and CO2. No other metabolic pathways have been identified for sevoflurane.
  • Half life9.5 min (Sevoflurane); 55 h (HFIP glucuronide)
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)LD50=10.8 g/kg
  • LD50 (mouse)N/A