- Molecular NameDiethylcarbamazine
- SynonymCarbamazine; Carbilazine; Diethyl carbamazine; Ditrazine base; Ethodryl
- Weight199.298
- Drugbank_IDDB00711
- ACS_NO90-89-1
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)1.19
- pkaN/A
- LogD (pH=7, predicted)0.98
- Solubility (experiment)750 g/L at 20?C for the citrate salt.
- LogS (predicted, ACD/Labs)(ph=7)-1.32
- LogSw (predicted, AB/LogsW2.0)314.23
- Sw (mg/ml) (predicted, ACD/Labs)4.54
- No.of HBond Donors0
- No.of HBond Acceptors4
- No.of Rotatable Bonds2
- TPSA26.79
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half life10 h under alkaline urinary pH conditions or 3 h if an acidic urinary pH is maintained.
- ExcretionAbout 50% of a dose is excreted in the urine as unchanged drug and 10% as the N-oxide metabolite in 48 h; the excretion of unchanged drug is pH-dependent being increased in acidic urine (pH 5) but decreasing to less than 10% in alkaline urine (pH 8).
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)1400 mg/kg
- LD50 (mouse)660 mg/kg