- Molecular NameGuaifenesin
- SynonymGlycerin guaiacolate; Glycerin monoguaiacol ether; Glycero-guaiacol ether; Glycerol guaiacolate; Glyceryl guaiacol; Glyceryl guaiacol ether; Glyceryl guaiacolate; Glyceryl guaiacolate ether; Glyceryl guaiacyl ether; Glyceryl guaicolate; Glyceryl guiacolate; Guiaphenesin; Metfenossidiolo; Methoxypropanediol; Methphenoxydiol; Metossipropandiolo; o-Methoxyphenyl glyceryl ether
- Weight198.218
- Drugbank_IDDB00874
- ACS_NO93-14-1
- Show 2D model
- LogP (experiment)1.39
- LogP (predicted, AB/LogP v2.0)0.68
- pkaN/A
- LogD (pH=7, predicted)0.68
- Solubility (experiment)50 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.1
- LogSw (predicted, AB/LogsW2.0)9.7
- Sw (mg/ml) (predicted, ACD/Labs)15.74
- No.of HBond Donors2
- No.of HBond Acceptors4
- No.of Rotatable Bonds5
- TPSA58.92
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn expectorant drug sold over the counter and usually taken by mouth to assist the bringing up ("expectoration") of phlegm from the airways in acute respiratory tract infections.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)1 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is rapidly metabolised by oxidation to β-(2-methoxyphenoxy)lactic acid
- Half life1 h (Blood half-life)
- Excretionabout 40% of a dose is excreted as this metabolite in the urine in 3 h.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityIn a fatality due to ingestion of cough syrup containing guaifenesin and hydrocodone, postmortem blood concentrations of 14 and 3 mg/L respectively were reported [R. H. Cravey per R. C. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 5th Edn, Davis, California, Biomedical Publications, 2000, pp 397–398.]
- LD50 (rat)LD50 = 1510 mg/kg
- LD50 (mouse)N/A