• Molecular NameNitrofurazone
  • SynonymNF; NFZ; Nitrofurazan
  • Weight198.138
  • Drugbank_IDDB00336
  • ACS_NO59-87-0
  • Show 2D model
  • LogP (experiment)0.23
  • LogP (predicted, AB/LogP v2.0)0.52
  • pka10
  • LogD (pH=7, predicted)0.52
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-2.47
  • LogSw (predicted, AB/LogsW2.0)0.35
  • Sw (mg/ml) (predicted, ACD/Labs)0.68
  • No.of HBond Donors3
  • No.of HBond Acceptors8
  • No.of Rotatable Bonds3
  • TPSA129.45
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyUsed as an antibiotic most commonly in the form of ointments. Its use in medicine has become less frequent as safer and more effective products have become available.
  • Absorption_valueN/A
  • Absorption (description)Well absorbed.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmNitrofurans, including nitrofural, undergo metabolic reduction at the nitro group to generate reactive species which can covalently bind to cellular macromolecules.
  • Half life5 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityAllergic contact dermatitis is the most frequently reported adverse effect, occurring in approximately 1 % of patients treated.
  • LD50 (rat)LD50=590 mg/kg
  • LD50 (mouse)N/A