• Molecular NameHalothane
  • Synonym2-Bromo-2-Chloro-1,1,1-Trifluoroethane; Alotano [Dcit]; Bromchlortrifluoraethanum; Bromochlorotrifluoroethane; Cf3chclbr; Fluorotane; Fluorothane; Freon 123b1; Ftorotan [Russian]; Ftuorotan; Halotano [INN-Spanish]; Halothan; Halothanum [INN-Latin]; Narcotann Ne-Spofa [Russian]
  • Weight197.381
  • Drugbank_IDDB01159
  • ACS_NO151-67-7
  • Show 3D model
  • LogP (experiment)2.3
  • LogP (predicted, AB/LogP v2.0)2.36
  • pkaN/A
  • LogD (pH=7, predicted)2.36
  • Solubility (experiment)3.45 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.76
  • LogSw (predicted, AB/LogsW2.0)2.17
  • Sw (mg/ml) (predicted, ACD/Labs)0.34
  • No.of HBond Donors0
  • No.of HBond Acceptors0
  • No.of Rotatable Bonds1
  • TPSA0.0
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn inhalational general anaesthetic.
  • Absorption_valueN/A
  • Absorption (description)Rapidly absorbed upon inhalation; blood:gas partition coefficient about 2.4.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic (CYP2E1). A variable amount is metabolised in the liver by debromination and dechlorination; replacement of a fluorine atom by a methoxy group followed by glucuronic acid conjugation occurs to a limited extent. Other metabolites which have been detected in expired air and in blood are 2-chloro-1,1,1-trifluoroethane and 2-chloro-1,1-difluoroethylene.
  • Half lifeN/A
  • ExcretionAbout 60 to 80% of an absorbed dose is exhaled unchanged from the lungs in 24 h and smaller amounts continue to be exhaled for several days or weeks. Up to about 20% of a dose may be excreted in the urine as trifluoroacetic acid and its salts. Bromide ion is slowly excreted in the urine.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityThe minimum lethal dose by ingestion or inhalation is about 10 mL although one case of recovery after the ingestion of 250 mL has been reported. Blood concentrations of 7 to 40 to 310 mg/L have been associated with fatalities.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A