• Molecular NameIsoproterenol
  • SynonymEpinephrine Isopropyl Homolog; IPA; Isoprenalin; Isoprenaline; Isopropydrin; Isopropyladrenaline; Isopropylarterenol; Isopropylnoradrenaline; Isopropylnorepinephrine; Isoproterenol Chloride; Isoproterenol HCl; L-Isopropylnoradrenaline; L-Isoproterenol; N-Isopropylnoradrenaline; N-Isopropylnorepinephrine
  • Weight197.234
  • Drugbank_IDDB01064
  • ACS_NO7683-59-2
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)-0.49
  • pka8.6, 10.1, 12.0
  • LogD (pH=7, predicted)-2.49
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.16
  • LogSw (predicted, AB/LogsW2.0)120.58
  • Sw (mg/ml) (predicted, ACD/Labs)72.68
  • No.of HBond Donors4
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds3
  • TPSA72.72
  • StatusFDA approved
  • Administrationinhalation
  • PharmacologyA sympathomimetic beta adrenergic agonist medication.
  • Absorption_valueN/A
  • Absorption (description)Isoproterenol is readily absorbed when given parenterally or as an aerosol.
  • Caco_2N/A
  • Bioavailability0.0
  • Protein bindingN/A
  • Volume of distribution (VD)0.5 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmIsoproterenol is metabolized primarily in the liver and other tissues by COMT.
  • Half life3~7 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityThe following reactions to isoproterenol hydrochloride injection have been reported: nervousness, headache, dizziness, tachycardia, palpitations, angina, Adams- Stokes attacks, pulmonary edema, hypertension, hypotension, ventricular arrhythmias, tachyarrhythmia, dyspnea flushing of the skin, sweating, mild tremors, weakness.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A