• Molecular NameMetyrosine
  • SynonymMethyltyrosine; Metirosine
  • Weight195.218
  • Drugbank_IDDB00765
  • ACS_NO672-87-7
  • Show 3D model
  • LogP (experiment)-1.475
  • LogP (predicted, AB/LogP v2.0)-1.8
  • pkaN/A
  • LogD (pH=7, predicted)-1.8
  • Solubility (experiment)0.57 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-1.02
  • LogSw (predicted, AB/LogsW2.0)1.38
  • Sw (mg/ml) (predicted, ACD/Labs)18.43
  • No.of HBond Donors4
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds3
  • TPSA83.55
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn antihypertensive drug. It inhibits the enzyme tyrosine hydroxylase and, therefore, catecholamine synthesis, which consequently depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body.
  • Absorption_valueN/A
  • Absorption (description)Well absorbed from the gastrointestinal tract.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmLittle biotransformation
  • Half life3.4~3.7 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySigns of metyrosine overdosage include those central nervous system effects observed in some patients even at low dosages.
  • LD50 (rat)LD50=752 mg/kg
  • LD50 (mouse)LD50=442 mg/kg