• Molecular NameMinoxidil
  • SynonymMinossidile [Italian]; Minoxidilum [INN-Latin]
  • Weight194.238
  • Drugbank_IDDB00350
  • ACS_NO38304-91-5
  • Show 3D model
  • LogP (experiment)1.24
  • LogP (predicted, AB/LogP v2.0)1.97
  • pka4.61
  • LogD (pH=7, predicted)1.97
  • Solubility (experiment)2200 mg/L
  • LogS (predicted, ACD/Labs)(ph=7)-1.61
  • LogSw (predicted, AB/LogsW2.0)9.69
  • Sw (mg/ml) (predicted, ACD/Labs)4.71
  • No.of HBond Donors2
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds1
  • TPSA67.61
  • StatusFDA approved
  • AdministrationOral / topical
  • PharmacologyA vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth.
  • Absorption_value96.0
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding0.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmApproximately 90% of the administered drug is metabolized, predominantly by conjugation with glucuronic acid at the N-oxide position in the pyrimidine ring, but also by conversion to more polar products. Known metabolites exert much less pharmacologic effect than minoxidil itself.
  • Half life3~4 h
  • Excretionrenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityMinoxidil is highly toxic to cats and may cause death. Side effects include cardiovascular effects associated with hypotension such as sudden weight gain, rapid heart beat, faintness or dizziness.
  • LD50 (rat)LD50=1321-3492 mg/kg
  • LD50 (mouse)LD50=2456-2648 mg/kg