• Molecular NameTocainide
  • SynonymTocainida [INN-Spanish]; Tocainidum [INN-Latin]
  • Weight192.262
  • Drugbank_IDDB01056
  • ACS_NO41708-72-9
  • Show 2D model
  • LogP (experiment)0.56
  • LogP (predicted, AB/LogP v2.0)0.6
  • pka7.8
  • LogD (pH=7, predicted)-0.43
  • Solubility (experiment)10.7 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.67
  • LogSw (predicted, AB/LogsW2.0)7.76
  • Sw (mg/ml) (predicted, ACD/Labs)7.79
  • No.of HBond Donors3
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds2
  • TPSA55.12
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA class Ib antiarrhythmic agent.
  • Absorption_value100.0
  • Absorption (description)Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.
  • Caco_2N/A
  • Bioavailability95.0
  • Protein binding13.0
  • Volume of distribution (VD)2.8~3.2 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmNegligible first pass hepatic degradation. No active metabolites have been found.
  • Half life14 h
  • Excretion30-50% urine (unchanged)
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityDeaths were usually preceded by convulsions.
  • LD50 (rat)LD50=1000 mg/kg
  • LD50 (mouse)LD50=800 mg/kg