• Molecular NameIsosorbide-2-monoitrate
  • SynonymNA
  • Weight191.139
  • Drugbank_IDDB01020
  • ACS_NO16051-77-7
  • Show 3D model
  • LogP (experiment)-0.15
  • LogP (predicted, AB/LogP v2.0)0.15
  • pkaN/A
  • LogD (pH=7, predicted)0.15
  • Solubility (experiment)107 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.38
  • LogSw (predicted, AB/LogsW2.0)2.67
  • Sw (mg/ml) (predicted, ACD/Labs)80.05
  • No.of HBond Donors1
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds2
  • TPSA96.75
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyIsosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris.
  • Absorption_value100.0
  • Absorption (description)Isosorbide mononitrate is rapidly and almost completely absorbed after oral or sublingual administration.
  • Caco_2N/A
  • Bioavailability100.0
  • Protein binding5.0
  • Volume of distribution (VD)0.6 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmIt is metabolised by enzymatic denitration and by glucuronide conjugation.
  • Half life3~7 h
  • ExcretionAbout 80% of a dose is excreted in the urine in 24 h.
  • Urinary ExcretionN/A
  • Clerance1~2 ml/min/kg
  • ToxicitySymptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A