- Molecular NameAzelaic Acid
- SynonymAnchoic acid; Azalaic Acid; Azelainic acid; Heptanedicarboxylic acid; Lepargylic acid; n-Nonanedioic acid; Nonanedioic acid
- Weight188.223
- Drugbank_IDDB00548
- ACS_NO123-99-9
- Show 3D model
- LogP (experiment)1.646
- LogP (predicted, AB/LogP v2.0)1.68
- pka4.55
- LogD (pH=7, predicted)-2.42
- Solubility (experiment)2.4 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)0.73
- LogSw (predicted, AB/LogsW2.0)3.99
- Sw (mg/ml) (predicted, ACD/Labs)9.08
- No.of HBond Donors2
- No.of HBond Acceptors4
- No.of Rotatable Bonds8
- TPSA74.6
- StatusFDA approved
- AdministrationTopical
- PharmacologyIt is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMainly excreted unchanged in the urine but undergoes some b-oxidation to shorter chain dicarboxylic acids.
- Half lifeThe observed half-lives in healthy subjects are approximately 45 minutes after oral dosing and 12 hours after topical dosing, indicating percutaneous absorption rate-limited kinetics.
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityOral, rat: LD50 = >5 gm/kg.
- LD50 (rat)N/A
- LD50 (mouse)N/A