- Molecular NameEnflurane
- SynonymAnesthetic 347; Anesthetic Compound No; 347; Compound 347; Enflurano [INN-Spanish]; Enfluranum [INN-Latin]; Methylflurether; Ohio 347
- Weight184.491
- Drugbank_IDDB00228
- ACS_NO13838-16-9
- Show 3D model
- LogP (experiment)2.1
- LogP (predicted, AB/LogP v2.0)2.06
- pkaN/A
- LogD (pH=7, predicted)2.06
- Solubility (experiment)5.620 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.49
- LogSw (predicted, AB/LogsW2.0)2.37
- Sw (mg/ml) (predicted, ACD/Labs)5.91
- No.of HBond Donors0
- No.of HBond Acceptors1
- No.of Rotatable Bonds3
- TPSA9.23
- StatusFDA approved
- AdministrationN/A
- PharmacologyA halogenated ether that was commonly used for inhalational anesthesia during the 1970s and 1980s.
- Absorption_valueN/A
- Absorption (description)Readily absorbed on inhalation.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding97.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- Metabollsm2.4% of the dose is slowly metabolized hepatically via oxidation and dehalogenation (primarily through the actions of cytochrome P450 2E1). Leads to low levels of serum fluoride (15 ?mol/L).
- Half life36 h
- ExcretionAbout 50% of a dose is exhaled unchanged in 18 h and more than 80% is exhaled in 5 days. Less than 5% of a dose is excreted in the urine as non-volatile metabolites. Difluoromethoxydifluoroacetic acid has been identified as a urinary metabolite.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of acute overdose include nausea, vomiting, irritation to the eyes, skin and nose/throat, headache, dizziness, and drowsiness. Symptoms of chronic overdose include hypotension, cardiac arrhythmias, respiratory depression, and liver/kidney dysfunction.
- LD50 (rat)LD50=5.4 ml/kg
- LD50 (mouse)N/A