- Molecular NameBarbital
- SynonymNA
- Weight184.195
- Drugbank_IDN/A
- ACS_NO57-44-3
- Show 3D model
- LogP (experiment)0.65
- LogP (predicted, AB/LogP v2.0)0.69
- pka8.0
- LogD (pH=7, predicted)0.64
- Solubility (experiment)7.4 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.49
- LogSw (predicted, AB/LogsW2.0)4.17
- Sw (mg/ml) (predicted, ACD/Labs)5.31
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds2
- TPSA75.27
- StatusN/A
- AdministrationN/A
- PharmacologyThe first commercially marketed barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding20.0
- Volume of distribution (VD)0.5 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half life2 days
- ExcretionIt is excreted slowly in the urine almost entirely as unchanged drug; about 2% of a dose is excreted in 8 h, about 16% in 32 h, and detectable amounts may still be present in the urine after 16 days.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityThe estimated minimum lethal dose is 2 g. Toxic effects may be produced with blood concentrations of about 20 mg/L or more, and concentrations greater than 90 mg/L may be lethal. In 6 cases of acute poisoning, the amounts ingested ranged from 5 to about 25 g. In 2 cases, death ensued after 150 and 160 h when the serum concentrations were about 100 and 170 mg/L respectively. In the other 4 cases, the serum concentrations on awakening from coma were 70 to 150 μg/L. [P. Lous,Acta Pharmacol. Toxicol.,1954, 10, 147–165 and P. Lous, Acta Pharmacol. Toxicol., 1954, 10, 261–280.]
- LD50 (rat)N/A
- LD50 (mouse)N/A