- Molecular NameChlorphentermine
- Synonym1-(4-Chlorophenyl)-2-methyl-2-propanamine; 1-(p-Chlorophenyl)-2-methyl-2-aminopropane; 1-(p-Chlorophenyl)-2-methyl-2-aminopropane hydrochloride; 4-Chloro-alpha,alpha-dimethylbenzeneethanamine; 4-Chloro-alpha,alpha-dimethylphenethylamine; alpha,alpha-dimethyl-p-chlorophenethylamine; Beta-(p-chlorophenyl)-alpha,alpha-dimethylethylamine; Chlorophentermine; Chlorophentermine hydrochloride; Chlorpentermine; Chlorphenteramine; Chlorphentermine hydrochloride; Chlorphenterminum [inn-latin]; Chlorphenterminum hydrochloride; Clorfentermina [inn-spanish]; P-chloro-alpha,alpha-dimethylphenethylamine; P-chlorphentermine hydrochloride
- Weight183.682
- Drugbank_IDN/A
- ACS_NO461-78-9
- Show 3D model
- LogP (experiment)2.6
- LogP (predicted, AB/LogP v2.0)2.45
- pkaN/A
- LogD (pH=7, predicted)0.2
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.18
- LogSw (predicted, AB/LogsW2.0)0.16
- Sw (mg/ml) (predicted, ACD/Labs)0.8
- No.of HBond Donors2
- No.of HBond Acceptors1
- No.of Rotatable Bonds2
- TPSA26.02
- StatusEU withdrawn, US withdrawn
- AdministrationOral, Insufflated, Rectal
- PharmacologyA stimulant drug which was used as an appetite suppressant.
- Absorption_valueN/A
- Absorption (description)Absorbed after oral administration
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)2 to 3 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMetabolised mainly by N-oxidation and N-hydroxylation to nitro, nitroso and hydroxylamine derivatives.
- Half life40 h
- ExcretionExcretion in the urine is dependent upon urinary pH, a much greater proportion of unchanged drug being excreted when the urine is acidic than when it is alkaline. In normal urine, about 17% of a dose is excreted unchanged and about 50% as N-oxidised metabolites in 48 h. If the urine is maintained at an acid pH, these proportions are approximately reversed, about 70% of a dose being excreted in 24 h. In alkaline urine less than 12% of a dose is excreted unchanged in 48 h.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A