• Molecular NameSuccimer
  • SynonymDimercaptosuccinic acid; DMSA
  • Weight182.22
  • Drugbank_IDDB00566
  • ACS_NO304-55-2
  • Show 2D model
  • LogP (experiment)0.048
  • LogP (predicted, AB/LogP v2.0)-0.02
  • pkaN/A
  • LogD (pH=7, predicted)-5.02
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)0.74
  • LogSw (predicted, AB/LogsW2.0)67.39
  • Sw (mg/ml) (predicted, ACD/Labs)7.15
  • No.of HBond Donors2
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds3
  • TPSA152.2
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn antidote to heavy metal poisoning because it forms strong chelates with them.
  • Absorption_valueN/A
  • Absorption (description)Rapid but variable.
  • Caco_2N/A
  • Bioavailability20.0
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmChemical analysis of succimer and its metabolites (primarily mixed disulfides of L-cysteine) in the urine showed that succimer was rapidly and extensively metabolized however the specific site of biotransformation is not known.
  • Half life48 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityNo case of overdosage has been reported in humans. Limited data indicate that succimer is dialyzable.
  • LD50 (rat)LD50>2300 mg/kg
  • LD50 (mouse)LD50>5011 mg/kg