- Molecular NameMannitol
- SynonymCordycepic acid; D-Mannitol; mannitol
- Weight182.172
- Drugbank_IDDB00742
- ACS_NO69-65-8
- Show 3D model
- LogP (experiment)-3.506
- LogP (predicted, AB/LogP v2.0)-3.08
- pka13.5
- LogD (pH=7, predicted)-3.08
- Solubility (experiment)216 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)0.74
- LogSw (predicted, AB/LogsW2.0)879.48
- Sw (mg/ml) (predicted, ACD/Labs)1000.0
- No.of HBond Donors6
- No.of HBond Acceptors6
- No.of Rotatable Bonds5
- TPSA121.38
- StatusFDA approved
- AdministrationIntravenous, Oral
- PharmacologyAn osmotic diuretic agent and a weak renal vasodilator.
- Absorption_value19.0
- Absorption (description)Only a small amount of mannitol is absorbed from the gastro-intestinal tract after ingestion
- Caco_2-6.21
- Bioavailability7.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is metabolised only very slightly to glycogen in the liver.
- Half lifeIn healthy volunteers the plasma half-life is 0.25 to 1.7 h and in those with renal failure, 6 to 36 h.
- ExcretionRenal: 90%. Following (IV) intravenous injection it is excreted rapidly by the kidneys before metabolism can take place in the liver. It is freely filtered by the glomeruli and undergoes tubular reabsorption. It does not cross the blood–brain barrier, unless in very high concentrations, or penetrate the eye. Distributed in the extracellular fluid.
- Urinary ExcretionN/A
- Clerance125 ml/h/kg in men and 116 ml/h/kg in women
- ToxicityMannitol is mildly toxic by ingestion, intraperitoneal and intravenous routes. It may cause blood pressure elevation, bladder tubule changes, nausea or vomiting. When heated to decomposition it emits acrid smoke and fumes.
- LD50 (rat)LD50=1700 mg/kg
- LD50 (mouse)N/A