• Molecular NameProthionamide
  • SynonymNA
  • Weight180.275
  • Drugbank_IDN/A
  • ACS_NO14222-60-7
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)1.72
  • pkaN/A
  • LogD (pH=7, predicted)1.72
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-1.97
  • LogSw (predicted, AB/LogsW2.0)2.89
  • Sw (mg/ml) (predicted, ACD/Labs)1.93
  • No.of HBond Donors2
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds3
  • TPSA71.0
  • StatusN/A
  • AdministrationN/A
  • PharmacologyA drug used in the treatment of tuberculosis.
  • Absorption_value100.0
  • Absorption (description)Essentially completely absorbed following oral administration and not subjected to any appreciable first pass metabolism. Bioavailability approximately 100%.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic and extensive. Metabolized to the active metabolite sulfoxide, and several inactive metabolites. The sulphoxide metabolite has been demonstrated to have antimicrobial activity against Mycobacterium tuberculosis.
  • Half life2~3 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include convulsions, nausea, and vomiting.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A