• Molecular NameRimantadine
  • SynonymRimantadine Hydrochloride
  • Weight179.307
  • Drugbank_IDDB00478
  • ACS_NO13392-28-4
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)2.89
  • pkaN/A
  • LogD (pH=7, predicted)-0.06
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.03
  • LogSw (predicted, AB/LogsW2.0)0.41
  • Sw (mg/ml) (predicted, ACD/Labs)0.34
  • No.of HBond Donors2
  • No.of HBond Acceptors1
  • No.of Rotatable Bonds1
  • TPSA26.02
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn orally administered antiviral drug used to treat, and in rare cases prevent, influenzavirus A infection.
  • Absorption_valueN/A
  • Absorption (description)Well absorbed, with the tablet and syrup formulations being equally absorbed after oral administration.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding40.0
  • Volume of distribution (VD)21 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmFollowing oral administration, rimantadine is extensively metabolized in the liver with less than 25% of the dose excreted in the urine as unchanged drug. Glucuronidation and hydroxylation are the major metabolic pathways.
  • Half life25.4 h
  • ExcretionRenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityOverdoses of a related rug, amantadine, have been reported with adverse reactions consisting of agitation, hallucinations, cardiac arrhythmia and death.
  • LD50 (rat)LD50=640 mg/kg
  • LD50 (mouse)N/A