• Molecular NamePropofol
  • Synonym2,6-Diisopropylphenol; Diisopropylphenol
  • Weight178.275
  • Drugbank_IDDB00818
  • ACS_NO2078-54-8
  • Show 3D model
  • LogP (experiment)3.79
  • LogP (predicted, AB/LogP v2.0)3.74
  • pka11.1
  • LogD (pH=7, predicted)3.74
  • Solubility (experiment)0.124 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.03
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.17
  • No.of HBond Donors1
  • No.of HBond Acceptors1
  • No.of Rotatable Bonds2
  • TPSA20.23
  • StatusFDA approved
  • AdministrationIntravenous
  • PharmacologyA short-acting, intravenously administered hypnotic agent. Its uses include the induction and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. Propofol is also commonly used in veterinary medicine.
  • Absorption_value100.0
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding98.5
  • Volume of distribution (VD)1.7 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmPropofol is extensively metabolized by UGTs.
  • Half life3.5 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • Clerance27 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=32