- Molecular NameVitamin C
- SynonymAA; Ascorbate; Ascorbic Acid; L-Ascorbate; L-Ascorbic Acid; L-Lyxoascorbic Acid; L-Xyloascorbic Acid
- Weight176.124
- Drugbank_IDDB00126
- ACS_NO50-81-7
- Show 3D model
- LogP (experiment)-1.64
- LogP (predicted, AB/LogP v2.0)-2.49
- pkaN/A
- LogD (pH=7, predicted)-5.27
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.75
- LogSw (predicted, AB/LogsW2.0)848.4
- Sw (mg/ml) (predicted, ACD/Labs)1000.0
- No.of HBond Donors4
- No.of HBond Acceptors6
- No.of Rotatable Bonds2
- TPSA107.22
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn essential nutrient for humans, in which it functions as a vitamin. Ascorbate (an ion of ascorbic acid) is required for a range of essential metabolic reactions in all animals and plants. It is made internally by almost all organisms; notable mammalian exceptions are most or all of the order chiroptera (bats), and the entire suborder Anthropoidea (Haplorrhini) (tarsiers, monkeys and apes). It is also needed by guinea pigs and some species of birds and fish. Deficiency in this vitamin causes the disease scurvy in humans.
- Absorption_value100.0
- Absorption (description)70% to 90%. Ascorbic acid is absorbed in the body by both active transport and simple diffusion. Sodium Dependent Active Transport - Sodium-Ascorbate Co-Transporters (SVCTs) and Hexose transporters (GLUTs) are the two transporters required for absorption. SVCT1 and SVCT2 imported the reduced form of ascorbate across plasma membrane.
- Caco_2N/A
- Bioavailability100.0
- Protein binding0.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic. Ascorbic acid is reversibly oxidised (by removal of the hydrogen from the enediol group of ascorbic acid) to dehydroascorbic acid. The two forms found in body fluids are physiologically active. Some ascorbic acid is metabolized to inactive compounds including ascorbic acid-2-sulfate and oxalic acid.
- Half life30 min
- ExcretionRenal
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A