- Molecular NamePropylthiouracil
- SynonymProcasil; Propacil; Propilthiouracil; Propycil; Propyl-Thiorist; Propyl-Thiorit; Propyl-Thyracil; Propylthiorit; Propythiouracil; Prothiucil; Prothiurone; Prothycil; Prothyran; Protiural; PTU; Thiuragyl
- Weight170.236
- Drugbank_IDDB00550
- ACS_NO51-52-5
- Show 2D model
- LogP (experiment)1.0
- LogP (predicted, AB/LogP v2.0)0.19
- pka8.3
- LogD (pH=7, predicted)0.08
- Solubility (experiment)1.21 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.66
- LogSw (predicted, AB/LogsW2.0)1.11
- Sw (mg/ml) (predicted, ACD/Labs)0.33
- No.of HBond Donors2
- No.of HBond Acceptors3
- No.of Rotatable Bonds2
- TPSA73.22
- StatusFDA approved
- AdministrationN/A
- PharmacologyA thioamide drug used to treat hyperthyroidism (including Graves disease) by decreasing the amount of thyroid hormone
- Absorption_value76.0
- Absorption (description)Well absorbed following oral administration.
- Caco_2N/A
- Bioavailability85.0
- Protein binding80.0
- Volume of distribution (VD)0.4 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half life1~2 h
- ExcretionLess than 10% of the drug is excreted unchanged, the remaining fraction undergoing extensive hepatic metabolism via glucuronidation.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityOral, rat: LD50 = 1250 mg/kg.
- LD50 (rat)LD50=1250 mg/kg
- LD50 (mouse)N/A