- Molecular NameLevetiracetam
- Synonymlevetiracetam; Levetiracetam [INN]; Levetiracetamum [INN-Latin]; Levitiracetam
- Weight170.212
- Drugbank_IDDB01202
- ACS_NO102767-28-2
- Show 3D model
- LogP (experiment)-0.65
- LogP (predicted, AB/LogP v2.0)-0.63
- pkaN/A
- LogD (pH=7, predicted)-0.63
- Solubility (experiment)1040 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-0.94
- LogSw (predicted, AB/LogsW2.0)103.38
- Sw (mg/ml) (predicted, ACD/Labs)19.5
- No.of HBond Donors2
- No.of HBond Acceptors4
- No.of Rotatable Bonds3
- TPSA63.4
- StatusFDA approved
- AdministrationN/A
- PharmacologyAn anticonvulsant medication used to treat epilepsy.
- Absorption_value100.0
- Absorption (description)Levetiracetam is rapidly and almost completely absorbed after oral administration. The extent of absorption is not affected by the presence of food but peak plasma concentrations may be reduced by approx. 20%, and time to reach these concentrations may be prolonged by approx. 1.5 h. Peak plasma concentrations are reached, generally, within one hour and steady state is achieved after two days of multiple twice daily dosing.
- Caco_2N/A
- Bioavailability100.0
- Protein binding10.0
- Volume of distribution (VD)0.5~0.7 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmThe major metabolic pathway is enzymatic hydrolysis which is not extensive and occurs in a number of tissues including blood cells. A carboxylic acid metabolite is produced. Two other minor metabolites have been detected; products of hydroxylation.
- Half life7 h; increased in the elderly and in subjects with renal impairment.
- ExcretionThe drug and its metabolites are excreted renally, with 66% of a dose excreted unchanged in urine.
- Urinary Excretion66
- Clerance0.96 ml/min/kg; reduced in the elderly and those with renal impairment—40% in patients with mild impairment, 50% moderate impairment and 60% for those with severe impairment; increased in paediatric patients by approx. 40%.
- ToxicitySide effects include aggression, agitation, coma, drowsiness, reduced consciousness, slowed breathing
- LD50 (rat)N/A
- LD50 (mouse)N/A