- Molecular NameChlorzoxazone
- SynonymChloroxazone; Chlorzoxane; Chlorzoxazon
- Weight169.567
- Drugbank_IDDB00356
- ACS_NO95-25-0
- Show 3D model
- LogP (experiment)1.659
- LogP (predicted, AB/LogP v2.0)2.04
- pka8.0
- LogD (pH=7, predicted)2.01
- Solubility (experiment)0.25 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.34
- LogSw (predicted, AB/LogsW2.0)0.14
- Sw (mg/ml) (predicted, ACD/Labs)0.76
- No.of HBond Donors1
- No.of HBond Acceptors3
- No.of Rotatable Bonds0
- TPSA38.33
- StatusFDA approved
- AdministrationN/A
- PharmacologyA centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.
- Absorption_value90.0
- Absorption (description)Absorbed after oral administration
- Caco_2N/A
- BioavailabilityN/A
- Protein binding15.5
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmRapidly metabolised to 6-hydroxychlorzoxazone.
- Half life1 h
- ExcretionUp to 90% of a dose is excreted in the urine in 48 h as conjugates of the 6-hydroxy metabolite; less than 1% is excreted as unchanged drug; 5-chloroacetanilide and 6-hydroxybenzoxazol-2(3H)-one have also been detected in urine.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose include diarrhea, dizziness, drowsiness, headache, light-headedness, nausea, and vomiting.
- LD50 (rat)Oral, rat: LD50 = 763 mg/kg
- LD50 (mouse)Oral, mouse: LD50 = 440 mg/kg