- Molecular NameDesflurane
- SynonymDesflurano [INN-Spanish]; Desfluranum [INN-Latin
- Weight168.036
- Drugbank_IDDB01189
- ACS_NO57041-67-5
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)1.69
- pkaN/A
- LogD (pH=7, predicted)1.69
- Solubility (experiment)Negligible
- LogS (predicted, ACD/Labs)(ph=7)-1.25
- LogSw (predicted, AB/LogsW2.0)5.72
- Sw (mg/ml) (predicted, ACD/Labs)9.5
- No.of HBond Donors0
- No.of HBond Acceptors1
- No.of Rotatable Bonds3
- TPSA9.23
- StatusFDA approved
- AdministrationInhalation
- PharmacologyA highly fluorinated methyl ethyl ether used for maintenance of general anesthesia.
- Absorption_valueN/A
- Absorption (description)bsorption, distribution and elimination following inhalation are more rapid than for other halogenated anaesthetics such as isoflurane or halothane. This is due to the low blood/gas coefficient of desflurane.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmAbout 0.02% of administered desflurane is metabolised in the liver; trifluoroacetic acid has been detected in the serum and urine of patients given desflurane.
- Half lifeElimination dependent on minute ventilation
- ExcretionThe majority of desflurane is excreted mainly unchanged through the lungs. A very small amount diffuses through the skin.
- Urinary ExcretionN/A
- Clerance4.6 L/min; pulmonary, 4.11 L/min
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A