- Molecular NameAmphotericin_B
- SynonymAMPH-B; Amphortericin B; amphotericin B; Amphotericine B; Liposomal Amphotericin B
- Weight940.09
- Drugbank_IDDB00681
- ACS_NO1397-89-3
- Show 2D model
- LogP (experiment)0.947
- LogP (predicted, AB/LogP v2.0)-0.85
- pka5.5, 10.0
- LogD (pH=7, predicted)-3.36
- Solubility (experiment)0.75 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-3.8
- LogSw (predicted, AB/LogsW2.0)1.18
- Sw (mg/ml) (predicted, ACD/Labs)0.14
- No.of HBond Donors14
- No.of HBond Acceptors19
- No.of Rotatable Bonds3
- TPSA339.84
- StatusFDA approved
- AdministrationSlow i.v.-infusion only
- PharmacologyA polyene antifungal drug, often used intravenously for systemic fungal infections.
- Absorption_value3.0
- Absorption (description)N/A
- Caco_2N/A
- Bioavailability3.0
- Protein binding90.0
- Volume of distribution (VD)0.76 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmRenal
- Half life18 h
- ExcretionIt is slowly excreted in the urine, less than 10% of a dose being excreted unchanged in 24 h; up to 40% of a dose is excreted in the urine in 7 days and traces are still detectable in urine 2 months after cessation of treatment.
- Urinary Excretion2~5
- Clerance0.46 ml/min/kg.
- ToxicityOral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.
- LD50 (rat)N/A
- LD50 (mouse)N/A